In this study, the authors show that topoisomerase-1–DNA cleavage complex (Top1cc) accumulation may be involved in the onset of ataxia telangiectasia and spinocerebellar ataxia with axonal neuropathy 1. In addition, they find that ATM regulates Top1cc levels in a kinase activity– and double-stranded break repair–independent manner.
- Sachin Katyal
- Youngsoo Lee
- Peter J McKinnon
