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Showing 1–3 of 3 results
Advanced filters: Author: Karin Siegmund Clear advanced filters

  • Respiratory complex I plays a key role in energy metabolism. Cryo-EM structure of a mutant accessory subunit LYRM6 from the yeast Yarrowia lipolytica and molecular dynamics simulations reveal conformational changes at the interface between LYRM6 and subunit ND3, propagated further into the complex. These findings offer insight into the mechanism of proton pumping by respiratory complex I.

    • Etienne Galemou Yoga
    • Kristian Parey
    • Heike Angerer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Proton pumping of mitochondrial complex I depends on the reduction of ubiquinone but the molecular mechanism of energy conversion is unclear. Here, the authors provide structural and biochemical evidence showing that movement of loop TMH1-2 in complex I subunit ND3 is required to drive proton pumping.

    • Alfredo Cabrera-Orefice
    • Etienne Galemou Yoga
    • Ulrich Brandt
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10