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Showing 1–7 of 7 results
Advanced filters: Author: Karin Straathof Clear advanced filters

  • Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratumoral injection of interleukin-12 helps condition the microenvironment and promote anti-tumor immunity.

    • Giulia Agliardi
    • Anna Rita Liuzzi
    • Burkhard Becher
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.

    • Matthew D. Young
    • Thomas J. Mitchell
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural crest lineage and suggest differentiation treatment with HDAC/mTOR inhibitors.

    • Lars Custers
    • Eleonora Khabirova
    • Jarno Drost
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling may inform immunotherapy approaches in paediatric patients with CNS tumour.

    • Yura Grabovska
    • Alan Mackay
    • Daniel Williamson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The authors describe a localized toxicity syndrome that is associated with immunotherapy treatment for CNS tumors and propose a new grading scale—with the goal of promoting research and standardizing both reporting and management.

    • Jasia Mahdi
    • Jorg Dietrich
    • Michelle Monje
    Reviews
    Nature Medicine
    Volume: 29, P: 803-810