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In the mouse ischaemic myocardium, neutrophils promote ventricular tachycardia via the secretion of resistin-like molecule-γ, according to a new study published in Science.

Cardiomyocytes can activate the type I interferon response in the infarct border zone after myocardial infarction, indicating that the type I interferon pathway, in addition to its well-established role in antiviral responses, is also involved in cardiac injury.

In aged mice, but not young mice, with atherosclerosis, depletion of CD8⁺ T cells significantly reduces atherosclerotic lesion size and necrotic core area.

In a study published in Nature, Jia and colleagues use advanced optical electrophysiology tools coupled with 3D-printed moulds to capture the very first heartbeat of zebrafish.

A single combined measurement of high-sensitivity C-reactive protein, LDL-cholesterol and lipoprotein(a) levels in plasma predicts incident cardiovascular events among women over a 30-year follow-up period, according to a new study.

Liu and colleagues demonstrate the crucial role of IL-6 signalling in the development of atherosclerosis driven by Tet2-related clonal haematopoiesis.

Deisseroth and colleagues used a novel optogenetic system to pace the heart and determine whether an increase in heart rate can evoke anxiety-like behaviours.

Poscablo and colleagues identify a distinct haematopoietic platelet differentiation pathway that is enriched in ageing mice, which results in platelets that are hyper-reactive compared with canonical platelet populations.

Findings from a new study published in Science Immunology suggest that epigenetic changes in haematopoietic stem cells promote the production of pro-inflammatory macrophages and influence their capacity to generate protective macrophage subsets.

According to a study published in Nature, the gut microbial metabolite imidazole propionate can induce atherosclerosis in atheroprone mice, further highlighting the role of microbiome-informed precision medicine to treat cardiovascular disease.

Two new papers describe the transcriptional programmes of congenital heart disease and dilated and hypertrophic cardiomyopathy assessed using single-nucleus RNA-sequencing technologies.

Inhibition of asialoglycoprotein receptor 1 (ASGR1) reduces cholesterol levels by promoting cholesterol excretion to bile and faeces.

After myocardial infarction, the heart secretes small extracellular vesicles with pro-neoplastic properties that can accelerate tumour growth when taken up by cancer cells.

In patients with carotid artery disease, the presence of microplastics and nanoplastics in the carotid plaque is associated with an increased risk of death or major cardiovascular events compared with patients in whom microplastics and nanoplastics were not detected.

In patients with symptomatic aortic stenosis and a small aortic annulus, a self-expanding valve has similar rates of clinical outcomes at 1 year and lower rates of bioprosthetic dysfunction compared with a balloon-expandable valve.

Heartbeat-induced pressure pulsations within arterial vessels in the brain can directly stimulate central neuronal activity by activating mechanosensitive channels in subsets of neurons, according to a study published in Science.

Using a porcine model of cardiogenic shock, Lamberti and colleagues develop a clinically accessible, patient-validated metric to assess pulmonary vascular compliance that can predict tolerance to left-sided ventricular assist device support.

Findings from the ORBITA-COSMIC trial show that treatment of patients with stable coronary artery disease using a coronary sinus reducer improves angina symptoms but does not increase transmural myocardial perfusion.

In the LIFE-BTK trial, treatment with an everolimus-eluting resorbable scaffold was superior to angioplasty in improving clinical outcomes in patients with chronic limb-threatening ischaemia due to infrapopliteal artery disease.

In the CASTLE HTx trial, patients with symptomatic atrial fibrillation and end-stage heart failure who underwent catheter ablation and received medical therapy had improved outcomes compared with patients who received medical therapy only.

In patients with severe calcified aortic valve stenosis, treatment with transthoracically delivered non-invasive ultrasound is safe and improves valve function.

During myocardial infarction, haematopoietic stem and progenitor cells increase fatty acid oxidation, and bone marrow adipocytes can act as a local energy resource for these cells.

In women with elevated levels of blood pressure during pregnancy, the use of a physician-guided remote telemonitoring programme during the postpartum period improves BP control, according to findings from the POP-HT trial.

The FIRE trial showed that complete revascularization improves outcomes in older patients with myocardial infarction (MI) and multivessel disease compared with culprit-lesion-only revascularization, whereas the MULTISTARS AMI trial reported that immediate multivessel revascularization is non-inferior to staged revascularization in patients with ST-segment elevation MI.

In a study published in Science, Wang and colleagues show that excited cardiomyocytes couple to fibroblasts via gap-junctional and non-gap-junctional (ephaptic) coupling.

Atherosclerotic plaques contain an abundance of T cells and macrophage subsets with distinct transcriptional signatures, according to a new study published in Nature Medicine.

Findings from the VIRGO study reveal that young women with acute myocardial infarction are more likely to be rehospitalized within 1 year compared with similarly aged men.

The FDA-approved drug ruxolitinib has been identified as an inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) that has the potential to be repurposed to treat arrhythmias induced by CaMKII hyperactivity.

Tricuspid transcatheter edge-to-edge repair in patients with severe tricuspid regurgitation improved quality of life and reduced disease severity compared with medical therapy

In the multicentre, randomized, placebo-controlled RAPID trial, use of symptom-prompted, self-administered, intranasally delivered etripamil was safe and superior to placebo for the conversion of paroxysmal superventricular tachycardia to sinus rhythm.

In patients with complex coronary lesions, percutaneous coronary intervention guided by intravascular imaging improved cardiovascular outcomes compared with percutaneous coronary intervention guided by angiography.

A study shows that macrophages undergo substantial expansion in the diseased atria of patients with atrial fibrillation (AF), and identifies two potential immunotherapy targets for the treatment of AF.

In the REPRIEVE trial, pitavastatin treatment in patients with human immunodeficiency virus (HIV) infection without pre-existing cardiovascular disease prevented cardiovascular events compared with placebo.

In a mouse model of atherosclerosis, a selective monoclonal antibody that blocks the binding of LDL to activin receptor-like kinase 1 reduced plaque formation in the aorta.

Desmosomal protein degradation that occurs via a mechanism involving the ubiquitin–proteasome system might underlie the development of arrhythmogenic cardiomyopathy.

Genetic analysis of multiorgan imaging data provided novel insights into the shared biology between the heart and the brain.

Findings from the STELLAR trial show that the addition of sotatercept to background therapy in patients with pulmonary arterial hypertension significantly improved exercise capacity compared with placebo.