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Showing 1–7 of 7 results
Advanced filters: Author: Karine Jamet Clear advanced filters

  • The role of telomeric factors as guardians of chromosome ends from threats to genome integrity (such as degradation and inappropriate DNA damage response activation) has long been appreciated. This Review discusses the extratelomeric activity of these factors and how they can regulate the transcription of genes involved in metabolism, immunity and differentiation.

    • Jing Ye
    • Valérie M. Renault
    • Eric Gilson
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 491-503

  • Analysis of the gut microbial gene composition in obese and non-obese individuals shows marked differences in bacterial richness between the two groups, with individuals with low richness exhibiting increased adiposity, insulin resistance, dyslipidaemia and inflammation; only a few bacterial marker species are needed to distinguish between individuals with high and low bacterial richness, providing potential for future diagnostic tools.

    • Emmanuelle Le Chatelier
    • Trine Nielsen
    • Oluf Pedersen
    Research
    Nature
    Volume: 500, P: 541-546

  • In obese and overweight individuals, diet-induced weight loss and weight-stabilization interventions improve the low microbiota gene richness and clinical phenotypes seen before intervention, but have less of an effect on inflammatory phenotypes.

    • Aurélie Cotillard
    • Sean P. Kennedy
    • Séverine Layec
    Research
    Nature
    Volume: 500, P: 585-588

  • Deep metagenomic sequencing and characterization of the human gut microbiome from healthy and obese individuals, as well as those suffering from inflammatory bowel disease, provide the first insights into this gene set and how much of it is shared among individuals. The minimal gut metagenome as well as the minimal gut bacterial genome is also described.

    • Junjie Qin
    • Ruiqiang Li
    • Jun Wang
    ResearchOpen Access
    Nature
    Volume: 464, P: 59-65