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Showing 1–12 of 12 results
Advanced filters: Author: Karine Lapouge Clear advanced filters

  • N-terminal acetylation is a common eukaryotic protein modification that is primarily catalysed by the N-acetyl transferase complex A (NatA). Here, the authors present the crystal structure of NatA bound to Huntingtin yeast two-hybrid protein K (HypK) and show that HypK is a negative regulator of NatA.

    • Felix Alexander Weyer
    • Andrea Gumiero
    • Irmgard Sinning
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • The RNA-binding ubiquitin E3 ligase TRIM25 plays a critical role in antiviral immunity. Here the authors identify key RNA-binding residues of TRIM25, link RNA binding to antiviral activity, reveal RNA structural and sequence preferences, and investigate binding to the viral genome.

    • Lucía Álvarez
    • Kevin Haubrich
    • Janosch Hennig
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Here, the authors elucidate how sequential activities of opposite-polarity microtubule motors are coordinated on a cargo, by showing how the Tm1 protein inhibits kinesin-1 during delivery of oskar RNA into the Drosophila oocyte by dynein.

    • Simone Heber
    • Mark A. McClintock
    • Anne Ephrussi
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 476-488

  • The ribosome-associated complex (RAC), which contains the Hsp40 protein Zuo1 and the non-canonical Hsp70 protein Ssz1 forms a chaperone triad with the fungal-specific Hsp70 protein Ssb. Here the authors combine X-ray crystallography, crosslinking and biochemical experiments and present the structure of the Zuo1 N-terminus bound to Ssz1 and demonstrate that Ssz1 is an active chaperone for nascent chains.

    • Ying Zhang
    • Genís Valentín Gesé
    • Irmgard Sinning
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunnel exit.

    • Klemens Wild
    • Milan Aleksić
    • Irmgard Sinning
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Blanpain and colleagues use mouse models of activated Hedgehog signalling to analyse the temporal gene expression changes involved in basal cell carcinoma initiation. They show that tumour initiation involves activation of the Wnt pathway and reprogramming of the adult interfollicular epidermis tumour-initiating cells into a cell fate resembling that of embryonic hair follicle progenitor cells.

    • Khalil Kass Youssef
    • Gaëlle Lapouge
    • Cédric Blanpain
    Research
    Nature Cell Biology
    Volume: 14, P: 1282-1294

  • Layer et al. present a crystal structure of Naa20, the catalytic subunit of an N-terminal acetyltransferase NatB, in complex with its competitive inhibitor CoA-Ac-MDEL. They find that Naa20 alone can acetylate NatB in vitro while Naa25, the auxiliary subunit of Naa20, increases the substrate affinity of Naa20. This study provides insights into the development of NAT inhibitors.

    • Dominik Layer
    • Jürgen Kopp
    • Irmgard Sinning
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12