The complex vascular pathobiology of sickle cell disease leads to renal manifestations that affect almost all physiological process in the kidney. Renal complications are diverse, ranging from altered haemodynamics and impaired urinary concentrating ability to glomerulopathies, chronic kidney disease, acute kidney injury and renal medullary carcinoma. In this Review, Karl A. Nath and Robert P. Hebbel provide an overview of sickle cell disease and consider the underlying pathogenetic mechanisms of the renal manifestations.
- Karl A. Nath
- Robert P. Hebbel
