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Showing 1–3 of 3 results
Advanced filters: Author: Karl Barry Sharpless Clear advanced filters

  • In this work, the authors present their Chloroalkane Azide Membrane Permeability (CHAMP) assay that measures cytosolic accumulation of small molecules in Escherichia coli, enabling rapid profiling of compounds, with the goal to simplify and accelerate antimicrobial drug discovery.

    • George M. Ongwae
    • Zichen Liu
    • Marcos M. Pires
    ResearchOpen Access
    Nature Communications
    P: 1-18

  • Microwave-assisted organic synthesis has considerable potential to accelerate the generation and optimization of lead compounds. Kappe and Dallinger outline the fundamental principles of this technology and discuss its applications in drug discovery.

    • C. Oliver Kappe
    • Doris Dallinger
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 51-63