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Showing 1–3 of 3 results
Advanced filters: Author: Karlijn van der Straten Clear advanced filters

  • There is still a need for effective HIV vaccines. In this phase I clinical trial, the authors show that an HIV-1 vaccine candidate, ConM SOSIP.v7, is well-tolerated in HIV-negative adults and that it elicits a strain-specific neutralising antibody response that differed between female and male participants.

    • Emma I. M. M. Reiss
    • Karlijn van der Straten
    • Godelieve J. de Bree
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Profiling antibody repertoires using proteomic approaches may provide a way of screening for antibody cross-reactivity against SARS-CoV-2 variants. Here the authors use a IgG1 specific cleavage method to analyse the IgG1 repertoire within recovered patients and relate this to antibody binding and neutralisation.

    • Danique M. H. van Rijswijck
    • Albert Bondt
    • Albert J. R. Heck
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell repertoire, authors identify following infection, a subset of B cells enriched and almost exclusively target a non-neutralizing S2 epitope present in aberrant forms.

    • Mathieu Claireaux
    • Tom G. Caniels
    • Marit J. van Gils
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15