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Showing 1–4 of 4 results
Advanced filters: Author: Karol Fiedorczuk Clear advanced filters

  • Hyperactivation of the cystic fibrosis transmembrane conductance regulator (CFTR) is central to the pathogenesis of secretory diarrheas and autosomal dominant polycystic kidney disease (ADPKD). Here, authors use cryo-EM to show that inhibitor (R)-BPO-27 inhibits CFTR via pore blockade

    • Paul G. Young
    • Karol Fiedorczuk
    • Jue Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • A paper reports the development of a universal tool for studying cellular interactions in biological systems, and demonstrates its coupling with single-cell transcriptomics methods to provide insights into the biology of the interactions.

    • Sandra Nakandakari-Higa
    • Sarah Walker
    • Gabriel D. Victora
    Research
    Nature
    Volume: 627, P: 399-406

  • Respirasomes are supercomplexes of mitochondrial electron transport chain complexes that are responsible for cellular respiration and energy production; cryo-electron microscopy structures of mammalian (sheep) respirasomes are presented.

    • James A. Letts
    • Karol Fiedorczuk
    • Leonid A. Sazanov
    Research
    Nature
    Volume: 537, P: 644-648

  • The atomic structure of ovine mitochondrial complex I is solved at 3.9 Å resolution, revealing that supernumerary subunits stabilize the complex and providing insight into the molecular basis of its function and regulation.

    • Karol Fiedorczuk
    • James A. Letts
    • Leonid A. Sazanov
    Research
    Nature
    Volume: 538, P: 406-410