Some large DNA viruses encode histone-like proteins similar to those in eukaryotes, which organize DNA into nucleosome-like particles. Here the authors find that Medusavirus histones form nucleosomes and arrays, but its unique linker histone H1 does not interact with chromatin. This reveals insights into how viruses organize their genetic material.
- Chelsea M. Toner
- Nicole M. Hoitsma
- Karolin Luger
