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Showing 1–5 of 5 results
Advanced filters: Author: Karoline T. Neumann Clear advanced filters

  • Marked ecosystem changes in the Baltic Sea have been recorded in the sediments, but the reasons are not fully understood. Now an integrated study of high-resolution sediment records (of the past 1,000 years) in combination with an ecosystem modelling approach reveals that surface temperature changes strongly influence deepwater oxygenation.

    • Karoline Kabel
    • Matthias Moros
    • Jaap S. Sinninghe Damsté
    Research
    Nature Climate Change
    Volume: 2, P: 871-874

  • Carbon isotope labelling of bioactive molecules is essential for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Here, the authors propose an electrochemical isotope-labelling protocol which enables the use of near-stoichiometric 14CO2, facilitating late-stage and single-step carbon-14 labelling of pharmaceuticals and representative precursors.

    • Gabriel M. F. Batista
    • Ruth Ebenbauer
    • Troels Skrydstrup
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • The direct carbon isotope exchange reaction on α-amino acids is highly desirable, as existing labelling methods require several synthetic steps and harsh conditions. Now, an aldehyde-catalysed carboxylate exchange with isotopically labelled *CO2 has enabled the direct formation of 11C, 13C and 14C-labelled α-amino acids.

    • Karoline T. Neumann
    • Troels Skrydstrup
    News & Views
    Nature Chemistry
    Volume: 14, P: 1339-1340