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Showing 1–2 of 2 results
Advanced filters: Author: Katarina Lopusna Clear advanced filters

  • The family of DNA methyltransferases (Dnmts) consists of four catalytically active enzymes that catalyze DNA methylation and also play a role as transcriptional regulators. Here the authors show that catalytically inactive Dnmt3b rescues a majority of methylation and expression changes in the absence of Dnmt3b during mouse embryonic development.

    • Pawel Nowialis
    • Katarina Lopusna
    • Rene Opavsky
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity in neurons and prime the TLR3-interferon pathway in astrocytes.

    • Line S. Reinert
    • Katarína Lopušná
    • Søren R. Paludan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12