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Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread

In this study, the authors present an analysis of 247 full-genome SARS-CoV-2 sequences obtained from two communities in Wisconsin, USA, and report distinct patterns of viral spread. Their results suggest that patterns of SARS-CoV-2 transmission and spread may vary substantially, even between neighbouring communities.

Gage K. Moreno
Katarina M. Braun
Thomas C. Friedrich
ResearchOpen Access03 Nov 2020
Nature Communications

Volume: 11, P: 1-13
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks

Transmission of influenza A viruses (IAV) between hosts and replication within host impose genetic bottlenecks, constraining viral diversity and adaptation. Here, Amato et al. perform site-specific inoculation of barcoded IAV of ferrets and track viral diversity as infection spreads to the lower respiratory tract and conclude that narrow population bottlenecks are an important feature of the within-host infection dynamics.

Katherine A. Amato
Luis A. Haddock III
Andrew Mehle
ResearchOpen Access14 Jun 2022
Nature Communications

Volume: 13, P: 1-15
The Effects of Altered Nutritional Status upon Insulin-Like Growth Factors and their Binding Proteins in Neonatal Rats

Anthony Philipps
Katarina Drakenberg
Vicki Sara
Research01 Aug 1989
Pediatric Research

Volume: 26, P: 128-134
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen

Carbohydrate-specific antibodies are typically thought to be of low affinity and produced by T cell–independent pathways. Wardemann and colleagues identify human memory B cells that can produce specific ‘affinity-matured’ antibodies to the O antigen of Klebsiella lipopolysaccharides.

Tim Rollenske
Valeria Szijarto
Hedda Wardemann
Research14 May 2018
Nature Immunology

Volume: 19, P: 617-624
Influenza evolution with little host selection

Influenza viruses undergo rapid antigenic evolution. Analysis of a large dataset of influenza virus sequences, using host age as a proxy for immune experience, shows no evidence for immune positive selection driving antigenic evolution in individual infected humans.

Katarina M. Braun
Thomas C. Friedrich
News & Views07 Jan 2019
Nature Ecology & Evolution

Volume: 3, P: 159-160
Signalling pathways and mechanistic cues highlighted by transcriptomic analysis of primordial, primary, and secondary ovarian follicles in domestic cat

Shauna Kehoe
Katarina Jewgenow
Beate C. Braun
ResearchOpen Access29 Jan 2021
Scientific Reports

Volume: 11, P: 1-17

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Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread

Mapping the human genetic architecture of COVID-19

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks

The Effects of Altered Nutritional Status upon Insulin-Like Growth Factors and their Binding Proteins in Neonatal Rats

A second update on mapping the human genetic architecture of COVID-19

Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen

Influenza evolution with little host selection

Signalling pathways and mechanistic cues highlighted by transcriptomic analysis of primordial, primary, and secondary ovarian follicles in domestic cat

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