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Showing 1–5 of 5 results
Advanced filters: Author: Katarzyna Janowska Clear advanced filters

  • In this study, Thakur et al determined cryo-EM structures of receptor-bound HIV-1 envelope (Env) to track how the fusion peptide transitions from being antibody accessible prior to receptor binding to becoming inaccessible in receptor-bound Env.

    • Bhishem Thakur
    • Revansiddha H. Katte
    • Priyamvada Acharya
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • HIV-1 is a formidable target for vaccine development. Here, Parthasarathy et al. show that envelope glycoproteins of some HIV-1 primary strains exhibit inherent conformational flexibility that may contribute to HIV-1 evasion from neutralizing antibodies.

    • Durgadevi Parthasarathy
    • Karunakar Reddy Pothula
    • Alon Herschhorn
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding domain (RBD) fluctuates between up or down conformations. Mutations engineered into the spike ectodomain either lock the RBD in the down state or make it adopt the up conformation more readily.

    • Rory Henderson
    • Robert J. Edwards
    • Priyamvada Acharya
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 925-933

  • The SARS-CoV-2 spike ectodomain is destabilized by cold temperature storage, an effect that can be reversed by incubation at 37 °C or by stabilizing its conformation in the ‘down’ state.

    • Robert J. Edwards
    • Katayoun Mansouri
    • Priyamvada Acharya
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 128-131