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Showing 1–8 of 8 results
Advanced filters: Author: Katayoun Mansouri Clear advanced filters

  • The SARS-CoV-2 spike ectodomain is destabilized by cold temperature storage, an effect that can be reversed by incubation at 37 °C or by stabilizing its conformation in the ‘down’ state.

    • Robert J. Edwards
    • Katayoun Mansouri
    • Priyamvada Acharya
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 128-131

  • The specifics of the pediatric immune response that gives rise to antibodies capable of neutralising diverse HIV-1 strains is not fully understood. Here the authors characterise the immune environment of Simian-HIV infected paediatric macaques and link to antibody neutralisation induction.

    • Sommer Holmes
    • Hui Li
    • Wilton B. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • Immunization of macaques with nanoparticle-conjugated receptor-binding domain of SARS-CoV-2 adjuvanted with 3M-052 and alum results in cross-neutralizing antibodies against bat coronaviruses, SARS-CoV and SARS-CoV-2 variants, and may provide a platform for developing pan-coronavirus vaccines.

    • Kevin O. Saunders
    • Esther Lee
    • Barton F. Haynes
    Research
    Nature
    Volume: 594, P: 553-559

  • The authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidate to neutralise SARS-CoV-2 variants of concern, and protect animals from other sarbecoviruses.

    • Dapeng Li
    • David R. Martinez
    • Barton F. Haynes
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • A pan-betacoronavirus vaccine will likely require the elicitation of antibodies against spike regions conserved across diverse coronaviruses. Here, authors computationally engineer and experimentally validate immunogens to elicit antibodies against two such spike regions.

    • A. Brenda Kapingidza
    • Daniel J. Marston
    • Mihai L. Azoitei
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Here, the authors report that specific monoclonal antibodies isolated from vaccinated rhesus macaques can neutralize a subset of Tier 2 difficult-to-neutralize HIV-1 that express Env in an open conformation, suggesting that V3 loop-specific targeting can bias the estimation of vaccine-induced bnAbs.

    • Qifeng Han
    • Julia A. Jones
    • Kevin O. Saunders
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The SARS-CoV-2 spike glycoprotein is flexible, and its receptor-binding domain (RBD) fluctuates between up or down conformations. Mutations engineered into the spike ectodomain either lock the RBD in the down state or make it adopt the up conformation more readily.

    • Rory Henderson
    • Robert J. Edwards
    • Priyamvada Acharya
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 925-933