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Showing 1–3 of 3 results
Advanced filters: Author: Katayoun Varzavand Clear advanced filters

  • BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity and bind to both DNA and H3K14ac simultaneously.

    • Emma A. Morrison
    • Julio C. Sanchez
    • Catherine A. Musselman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Here the 2.1 Å crystal structure of human immunodeficiency virus (HIV) Tat protein complexed with the positive transcription elongation factor P-TEFb is reported. This shows that Tat binding changes the structure of P-TEFb, which may suggest opportunities for developing inhibitors that block only the form of P-TEFb used by the virus.

    • Tahir H. Tahirov
    • Nigar D. Babayeva
    • David H. Price
    Research
    Nature
    Volume: 465, P: 747-751