Internalized transmembrane proteins can be recycled to the plasma membrane by SNX27–retromer-mediated transport. Cullen and colleagues have done a global analysis of retromer-mediated transport by combining quantitative proteomics to delineate the SNX27 interactome and an analysis of the surface proteome of SNX27- or retromer-suppressed cells. They show that the SNX27–retromer complex recycles proteins involved in maintaining cellular nutrient homeostasis and is required to prevent lysosomal degradation of the recycling cargoes.
- Florian Steinberg
- Matthew Gallon
- Peter J. Cullen
