Wang et al. describe a strategy for quantitatively performing composition analysis of heparan sulfate using 13C-labeled disaccharides and polysaccharides that mimic the glycosaminoglycan chemical structure. They further show that these isotopically labelled small molecules can be used as internal standards for mass spectrometry analysis of heparan sulfate derived from mouse tissue and plasma.
- Zhangjie Wang
- Katelyn Arnold
- Jian Liu
