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Showing 1–7 of 7 results
Advanced filters: Author: Katherine G. Zyner Clear advanced filters

  • Whether G-quadruplexes (G4s) regulate stem cell self-renewal and fate determination during embryonic development is not well understood. Here, the authors reveal that the embryonic stem cell state is defined by very high G4 abundance. G4s are progressively lost during differentiation as cells transit to lower lineage potential while artificial G4 stabilisation leads to delayed differentiation.

    • Katherine G. Zyner
    • Angela Simeone
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • G-quadruplexes formed by four guanine bases in a square planar arrangement in telomeres may prevent extension of this region by telomerase. Here, the authors show that telomerase can localize to and partially unwind and extend G-quadruplexes, suggesting an important biological role for G-quadruplexes.

    • Aaron L. Moye
    • Karina C. Porter
    • Tracy M. Bryan
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • G-quadruplexes (G4s) are structures formed in guanine-rich DNA or RNA, which are linked to transcription, translation, chromatin biology, genome instability and RNA modifications. Recent studies connect G4 formation with cancer-cell lethality and indicate that G4s could be therapeutic targets.

    • Dhaval Varshney
    • Jochen Spiegel
    • Shankar Balasubramanian
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 459-474

  • Quantitative ChIP–seq analysis maps G-quadruplex (G4) DNA structures in breast cancer patient-derived tumor xenograft (PDTX) models. G4-based subtypes highlight additional tumor heterogeneity in the integrative cluster (IC) system.

    • Robert Hänsel-Hertsch
    • Angela Simeone
    • Shankar Balasubramanian
    Research
    Nature Genetics
    Volume: 52, P: 878-883

  • Shankar Balasubramanian and colleagues examine endogenous DNA G-quadruplex (G4) structures in the context of chromatin by using G4 antibody-based ChIP–seq. They find that G4 structures are enriched in nucleosome-depleted regions and the promoters and 5′ UTRs of highly transcribed genes, suggesting a relationship between chromatin state, transcriptional output and G4 status.

    • Robert Hänsel-Hertsch
    • Dario Beraldi
    • Shankar Balasubramanian
    Research
    Nature Genetics
    Volume: 48, P: 1267-1272