Kelly Chacón et al. report insights into the mechanism of copper transfer between CusF and CusB, which are involved in heavy metal export as a part of bacterial host-defense strategies. Their results indicate fast formation of a complex involving a shared metallosite with ligands derived from each partner, followed by slower intra-complex metal transfer.
- Kelly N. Chacón
- Jonathan Perkins
- Ninian J. Blackburn