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Showing 1–7 of 7 results
Advanced filters: Author: Katherine L. Rothamel Clear advanced filters

  • The epigenetic mechanisms underlying pancreatic ductal adenocarcinoma (PDAC) are not fully elucidated. Here, the authors reveal a druggable super-enhancer-mediated RNA-binding protein cascade that supports PDAC growth through enhanced mRNA translation.

    • Corina E. Antal
    • Tae Gyu Oh
    • Ronald M. Evans
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS crystal structures, which will facilitate drug development.

    • Jessica Vincent
    • Carolina Adura
    • Manuel Ascano
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • RNA-binding proteins regulate the lifecycle of RNA, and their dysregulation is associated with diseases such as cancer and neurodegeneration. Using methods based on ultraviolet crosslinking followed by immunoprecipitation (CLIP), we can now begin to decode the mechanisms of the interactions between RNA-binding proteins and RNA. This Review discusses recent insights from and future applications of these methodologies.

    • Joy S. Xiang
    • Danielle M. Schafer
    • Gene W. Yeo
    Reviews
    Nature Reviews Genetics
    Volume: 25, P: 879-895

  • The transcriptional circuitry that controls the differentiation of hematopoietic stem cells into cells of the immune system is only partially understood. Koller and colleagues use a computational algorithm to identify previously unknown differentiation stage–specific regulators of mouse hematopoiesis.

    • Vladimir Jojic
    • Tal Shay
    • Shannon Turley
    Research
    Nature Immunology
    Volume: 14, P: 633-643

  • The differentiation of αβ T cells is a complex process. Using data sets from the Immunological Genome Project, Benoist and colleagues identify candidate mediators of key transitions during thymocyte selection and maturation.

    • Michael Mingueneau
    • Taras Kreslavsky
    • Shannon Turley
    Research
    Nature Immunology
    Volume: 14, P: 619-632