Some stress-related memories are state-dependent: they cannot be retrieved unless the brain is in the same state as during initial encoding. The authors show that hippocampal extrasynaptic GABAA receptors, regulated by miR-33, support state-dependent contextual fear conditioning by altering the processing of context memories within the extended hippocampal circuit.
- Vladimir Jovasevic
- Kevin A Corcoran
- Jelena Radulovic