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Showing 1–5 of 5 results
Advanced filters: Author: Katherine M. Bruner Clear advanced filters
  • Quantifying the total-body virus burden in HIV-infected individuals is necessary to understand viral persistence and guide development of cure strategies. Here, Estes et al. find a high burden of residual virus in tissues of SIV-infected monkeys and HIV-infected humans, and evidence of low-level viral replication, even under antiretroviral therapy.

    • Jacob D Estes
    • Cissy Kityo
    • Timothy W Schacker
    Research
    Nature Medicine
    Volume: 23, P: 1271-1276
  • Bruner et al. report that defective HIV-1 proviruses predominate in early infection, even when antiretroviral therapy is initiated in the first months after infection. The results highlight challenges in estimating the reservoir of intact, replication-competent virus that may influence cure strategies.

    • Katherine M Bruner
    • Alexandra J Murray
    • Robert F Siliciano
    Research
    Nature Medicine
    Volume: 22, P: 1043-1049
  • An assay to measure the latent HIV-1 reservoir that separately quantifies intact and defective proviruses will facilitate evaluation of HIV-1 cure strategies by measuring the provirues that pose a barrier to cure.

    • Katherine M. Bruner
    • Zheng Wang
    • Robert F. Siliciano
    Research
    Nature
    Volume: 566, P: 120-125
  • Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.

    • William F. Laurance
    • D. Carolina Useche
    • Franky Zamzani
    Research
    Nature
    Volume: 489, P: 290-294