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The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

The Legionella collagen-like protein (Lcl) is important for host adhesion in Legionella pneumophila. Here, the authors provide structural and biochemical data, which provides insights into a distinct “fuzzy” glycosaminoglycan binding mechanism.

Saima Rehman
Anna Katarina Antonovic
James A. Garnett
ResearchOpen Access08 Jun 2024
Nature Communications

Volume: 15, P: 1-16
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

COVID-19 booster immunizations aimed at spike protein from new SARS-CoV-2 variants induce robust germinal centre B cell responses against the original spike protein, as well as de novo B cell responses against the variant spike protein.

Wafaa B. Alsoussi
Sameer Kumar Malladi
Ali H. Ellebedy
Research03 Apr 2023
Nature

Volume: 617, P: 592-598
Trailing edge contractions common in interior western US trees under varying disturbances

Climate change and disturbances are changing forest tree composition, but it is not clear if disturbances assist trees in tracking their climate ranges. This study shows that the impact of disturbance on range shifts is dependent on the tree species and type of disturbance.

Katherine M. Nigro
Kristen Pelz
Miranda D. Redmond
Research07 Jan 2025
Nature Climate Change

Volume: 15, P: 196-200
Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Controversy exists over the function of plasma membrane versus intracellular vesicular LAT in T-cell receptor signaling. Here the authors use high resolution imaging of the temporal dynamics of LAT involvement to show that both sources of LAT are required, but at distinct stages.

Lakshmi Balagopalan
Jason Yi
Lawrence E. Samelson
ResearchOpen Access22 May 2018
Nature Communications

Volume: 9, P: 1-17
Human germinal centres engage memory and naive B cells after influenza vaccination

The human germinal centre response to influenza virus vaccination is fuelled by the continued recruitment of naive B cells as well as pre-existing memory B cells.

Jackson S. Turner
Julian Q. Zhou
Ali H. Ellebedy
Research31 Aug 2020
Nature

Volume: 586, P: 127-132
Influenza vaccination stimulates maturation of the human T follicular helper cell response

Schattgen et al. profiled the subsets and clonality of CD4⁺ T_FH cells in the blood and lymph nodes of human volunteers who received two influenza vaccines 1 year apart to characterize their dynamics and clonal evolution over 2 years.

Stefan A. Schattgen
Jackson S. Turner
Paul G. Thomas
ResearchOpen Access20 Aug 2024
Nature Immunology

Volume: 25, P: 1742-1753
TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

Engagement of T cell receptors (TCRs) induces the formation of microclusters that mediate the downstream signalling events. Here the authors show, using high resolution TIRF-SIM and live cell imaging, that ZAP70 and LAT are recruited to TCR with distinct kinetics, with the delayed ZAP70-TCR association modulated by TCR-induced calcium flux.

Jason Yi
Lakshmi Balagopalan
Lawrence E. Samelson
ResearchOpen Access17 Jan 2019
Nature Communications

Volume: 10, P: 1-13

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The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

Trailing edge contractions common in interior western US trees under varying disturbances

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Human germinal centres engage memory and naive B cells after influenza vaccination

Influenza vaccination stimulates maturation of the human T follicular helper cell response

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

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The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

Trailing edge contractions common in interior western US trees under varying disturbances

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Human germinal centres engage memory and naive B cells after influenza vaccination

Influenza vaccination stimulates maturation of the human T follicular helper cell response

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

Search

Quick links