Nature Search

Deep mitigation of CO₂ and non-CO₂ greenhouse gases toward 1.5 °C and 2 °C futures

Stabilizing climate change requires simultaneous mitigation of all greenhouse gas emissions (GHGs). Here the authors examine 90 mitigation scenarios pairing different levels of CO₂ and non-CO₂ GHG abatement pathways to demonstrate the contributions of different GHGs towards 1.5 °C and 2 °C goals.

Yang Ou
Christopher Roney
Haewon McJeon
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-9
A prion protein epitope selective for the pathologically misfolded conformation

Eustache Paramithiotis
Marc Pinard
Neil R Cashman
Research01 Jun 2003
Nature Medicine

Volume: 9, P: 893-899
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids.

Jatin Roper
Tuomas Tammela
Ömer H Yilmaz
Research01 May 2017
Nature Biotechnology

Volume: 35, P: 569-576
Synthesis of Wild Type and Mutant Human Hemoglobins in Saccharomyces cerevisiae

Michael Wagenbach
Katherine O'Rourke
Gary Stetler
Research01 Jan 1991
Bio/Technology

Volume: 9, P: 57-61
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Cox and colleagues develop PXS-5505, a first-in-class selective pan-lysyl oxidase inhibitor and show that it reduces chemotherapy-induced desmoplasia and stiffness, thereby improving chemotherapy response and survival in pancreatic cancer models.

Jessica L. Chitty
Michelle Yam
Thomas R. Cox
ResearchOpen Access28 Aug 2023
Nature Cancer

Volume: 4, P: 1326-1344
Reply to “Properties of a disease-specific prion probe”

Eustache Paramithiotis
Marc Pinard
Neil R Cashman
Correspondence01 Jan 2004
Nature Medicine

Volume: 10, P: 11-12
An image analysis toolbox for high-throughput C. elegans assays

The freely available WormToolbox enables high-throughput image analysis of a variety of phenotypes of Caenorhabditis elegans in liquid culture and should prove useful for image-based screens.

Carolina Wählby
Lee Kamentsky
Anne E Carpenter
Research22 Apr 2012
Nature Methods

Volume: 9, P: 714-716
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment.

Claire Vennin
Pauline Mélénec
Paul Timpson
ResearchOpen Access12 Aug 2019
Nature Communications

Volume: 10, P: 1-22
Microarray expression profiling in melanoma reveals a BRAF mutation signature

Sandra Pavey
Peter Johansson
Nicholas K Hayward
Research29 Mar 2004
Oncogene

Volume: 23, P: 4060-4067
Correction: BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway

Adam L. Green
John DeSisto
Rajeev Vibhakar
Amendments and Corrections22 Jan 2020
Oncogene

Volume: 39, P: 2641
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.

Vinod P. Balachandran
Marta Łuksza
Steven D. Leach
Research01 Nov 2017
Nature

Volume: 551, P: 512-516
BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway

Adam L. Green
John DeSisto
Rajeev Vibhakar
Research16 Dec 2019
Oncogene

Volume: 39, P: 2305-2327
Marked seasonal variation in the wild mouse gut microbiota

Corinne F Maurice
Sarah CL Knowles
Peter J Turnbaugh
ResearchOpen Access29 May 2015
The ISME Journal

Volume: 9, P: 2423-2434
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Genetics researchers’ and IRB professionals’ attitudes toward genetic research review: a comparative analysis

Karen L. Edwards
Amy A. Lemke
Wylie Burke
Research12 Jan 2012
Genetics in Medicine

Volume: 14, P: 236-242
The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study): a UK national observational cohort study

Lewis A. Hall
Siobhan C. McKay
Melissa Zhao
ResearchOpen Access23 Mar 2023
British Journal of Cancer

Volume: 128, P: 1922-1932
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Lakis et al. report novel findings related to the epigenetic landscape of pancreatic neuroendocrine cancer. This relatively large cohort provides functional insights into the epigenetic wiring of pancreatic neuroendocrine tumor sub-types with the potential ability to stratify tumours of different prognosis.

Vanessa Lakis
Rita T. Lawlor
Aldo Scarpa
ResearchOpen Access03 Feb 2021
Communications Biology

Volume: 4, P: 1-11

Search

Deep mitigation of CO₂ and non-CO₂ greenhouse gases toward 1.5 °C and 2 °C futures

A prion protein epitope selective for the pathologically misfolded conformation

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Synthesis of Wild Type and Mutant Human Hemoglobins in Saccharomyces cerevisiae

A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Reply to “Properties of a disease-specific prion probe”

An image analysis toolbox for high-throughput C. elegans assays

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Microarray expression profiling in melanoma reveals a BRAF mutation signature

Correction: BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway

Marked seasonal variation in the wild mouse gut microbiota

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Genetics researchers’ and IRB professionals’ attitudes toward genetic research review: a comparative analysis

The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study): a UK national observational cohort study

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

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