Nature Search

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress

Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.

Kevin Rhine
Rachel Li
Gene W. Yeo
ResearchOpen Access02 Jun 2025
Nature Neuroscience

Volume: 28, P: 1174-1184
Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent
Carolina Adura
Manuel Ascano
Amendments and CorrectionsOpen Access23 Nov 2017
Nature Communications

Volume: 8, P: 1
A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer

The epigenetic mechanisms underlying pancreatic ductal adenocarcinoma (PDAC) are not fully elucidated. Here, the authors reveal a druggable super-enhancer-mediated RNA-binding protein cascade that supports PDAC growth through enhanced mRNA translation.

Corina E. Antal
Tae Gyu Oh
Ronald M. Evans
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS crystal structures, which will facilitate drug development.

Jessica Vincent
Carolina Adura
Manuel Ascano
ResearchOpen Access29 Sept 2017
Nature Communications

Volume: 8, P: 1-13
Decoding protein–RNA interactions using CLIP-based methodologies

RNA-binding proteins regulate the lifecycle of RNA, and their dysregulation is associated with diseases such as cancer and neurodegeneration. Using methods based on ultraviolet crosslinking followed by immunoprecipitation (CLIP), we can now begin to decode the mechanisms of the interactions between RNA-binding proteins and RNA. This Review discusses recent insights from and future applications of these methodologies.

Joy S. Xiang
Danielle M. Schafer
Gene W. Yeo
Reviews09 Jul 2024
Nature Reviews Genetics

Volume: 25, P: 879-895
Viral crosslinking and solid-phase purification enables discovery of ribonucleoprotein complexes on incoming RNA virus genomes

This protocol describes a strategy for revealing the initial interactions between host proteins and incoming viral RNAs that relies on solid-phase purification of crosslinked RNA–protein complexes followed by mass spectrometry.

Byungil Kim
Sarah Arcos
Manuel Ascano
Protocols02 Dec 2020
Nature Protocols

Volume: 16, P: 516-531
The transcriptional landscape of αβ T cell differentiation

The differentiation of αβ T cells is a complex process. Using data sets from the Immunological Genome Project, Benoist and colleagues identify candidate mediators of key transitions during thymocyte selection and maturation.

Michael Mingueneau
Taras Kreslavsky
Shannon Turley
Research05 May 2013
Nature Immunology

Volume: 14, P: 619-632
Identification of transcriptional regulators in the mouse immune system

The transcriptional circuitry that controls the differentiation of hematopoietic stem cells into cells of the immune system is only partially understood. Koller and colleagues use a computational algorithm to identify previously unknown differentiation stage–specific regulators of mouse hematopoiesis.

Vladimir Jojic
Tal Shay
Shannon Turley
Research28 Apr 2013
Nature Immunology

Volume: 14, P: 633-643

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