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Showing 1–3 of 3 results
Advanced filters: Author: Kathleen Sprouffske Clear advanced filters

  • YAP activation is a key driver in both malignant pleural mesothelioma and uveal melanoma through engagement of different regulatory elements. Here, the authors use functional epigenomic analyses to reveal lineage-specific YAP-dependent cistrome.

    • Inês A. M. Barbosa
    • Rajaraman Gopalakrishnan
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.

    • Melusine Bleu
    • Swann Gaulis
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Using deep mutational scanning, the authors uncover the functional consequence of missense mutations in ARID1B, a subunit of the SWI/SNF chromatin remodeling complex that is frequently mutated in human Coffin–Siris syndrome and in cancer.

    • Fanny Mermet-Meillon
    • Samuele Mercan
    • Giorgio G. Galli
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1018-1022