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Showing 1–2 of 2 results
Advanced filters: Author: Kathrin Plitzko Clear advanced filters

  • Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, suppressing ChREBPβ and protecting β-cells from glucolipotoxicity, showcasing ‘molecular glues’ as tools to control difficult to target transcription factors.

    • Liora S. Katz
    • Emira J. Visser
    • Donald K. Scott
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Small molecule stabilizers of protein–protein interactions hold great therapeutic potential. Based on virtual screening and molecular docking, the authors here develop a strategy to evolve weak, promiscuous inhibitors of 14-3-3 interactions into selective stabilizers of the 14-3-3/ChREBP complex.

    • Eline Sijbesma
    • Emira Visser
    • Christian Ottmann
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9