Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Kathrin Thedieck Clear advanced filters

  • Sialic acid O-acetylation occurs in the Golgi apparatus and is catalyzed by CASD1, a multi-pass transmembrane protein. Here, the authors reveal that SLC33A1 delivers acetyl-CoA to the luminal catalytic domain of CASD1, while a catalytic transmembrane tunnel enables SLC33A1-independent O-acetylation.

    • Malena Albers
    • Lydia Bosse
    • Martina Mühlenhoff
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ sustains autophagy under non-starvation conditions.

    • Piero Dalle Pezze
    • Stefanie Ruf
    • Kathrin Thedieck
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19

  • Fatty acid unsaturation by stearoyl-CoA desaturase 1 (SCD1) protects against cellular stress through unclear mechanisms. Here the authors show 1,2-dioleoyl-sn-glycero-3-phospho-(1’-myo-inositol) is an SCD1-derived signaling lipid that regulates stress-adaption, protects against cell death and promotes proliferation.

    • Maria Thürmer
    • André Gollowitzer
    • Andreas Koeberle
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21