Atherosclerosis is accompanied by an autoimmune response that includes CD4 T cells recognizing epitopes in apolipoprotein B (APOB). Saigusa et al. analyzed the transcriptomes and T cell receptors of APOB-specific CD4 T cells by single-cell RNA sequencing using MHC-II tetramers in women with atherosclerosis, and showed that APOB-specific regulatory T cells switch to a more memory-like phenotype in atherosclerosis.
- Ryosuke Saigusa
- Payel Roy
- Klaus Ley
