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Communications Biology (1)

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Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

A high-throughput platform enables the production of single-chain trimers for any pairing of peptide and Class I HLA allele for rapid discovery of epitopes and capture of antigen-specific CD8 + T cells for functional characterization.

William Chour
Jongchan Choi
James R. Heath
ResearchOpen Access16 May 2023
Communications Biology

Volume: 6, P: 1-13

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Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

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