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Showing 1–8 of 8 results
Advanced filters: Author: Katina I. Spanier Clear advanced filters

  • Generating high-quality training data for machine learning is costly. Here, authors include sequence-to-function modeling in benchmarking of custom and commercial droplet-based scATAC platforms, and release a new Drosophila embryo atlas along with a new mouse cortex atlas, assessed for model interpretability.

    • Hannah Dickmänken
    • Marta Wojno
    • Stein Aerts
    ResearchOpen Access
    Nature Communications
    P: 1-17

  • Standing genetic variation allows natural populations to evolve rapidly. Genome sequences of a resurrected Daphnia population show that genetic variation carried by only five founding individuals from the regional genotype pool is enough to fuel rapid evolution in response to strong selection pressures with no evidence of genetic erosion.

    • Anurag Chaturvedi
    • Jiarui Zhou
    • Luc De Meester
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Deep learning models were used to design synthetic cell-type-specific enhancers that work in fruit fly brains and human cell lines, an approach that also provides insights into these gene regulatory elements.

    • Ibrahim I. Taskiran
    • Katina I. Spanier
    • Stein Aerts
    ResearchOpen Access
    Nature
    Volume: 626, P: 212-220

  • A chromatin accessibility atlas of 240,919 cells in the adult and developing Drosophila brain reveals 95,000 enhancers, which are integrated in cell-type specific enhancer gene regulatory networks and decoded into combinations of functional transcription factor binding sites using deep learning.

    • Jasper Janssens
    • Sara Aibar
    • Stein Aerts
    Research
    Nature
    Volume: 601, P: 630-636

  • The brain cell types of Octopus vulgaris that control their sophisticated behavioral repertoire are still unknown. Here, authors use single-cell transcriptomics to profile neuronal and glial cell types and compare cell type relationships within the octopus brain and across species.

    • Ruth Styfhals
    • Grygoriy Zolotarov
    • Eve Seuntjens
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17