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Showing 1–5 of 5 results
Advanced filters: Author: Katja Hebestreit Clear advanced filters

  • Sexual interactions with males shorten the lifespan of the opposite sex in several species, including Caenorhabditis elegans, but the mechanisms are not fully understood. Here the authors use transcriptomic profiling in C. elegans to systematically identify the genetic pathways involved in male-induced demise, which include upregulation of a conserved ion channel that regulates fat metabolism.

    • Lauren N. Booth
    • Cheng Shi
    • Anne Brunet
    ResearchOpen Access
    Nature Aging
    Volume: 2, P: 809-823

  • Single-cell transcriptomic analysis of neurogenic niches in young and old mice reveals that T cells infiltrate the neurogenic niches of old mice and inhibit the proliferation of neural stem cells, in part through expression of interferon-γ.

    • Ben W. Dulken
    • Matthew T. Buckley
    • Anne Brunet
    Research
    Nature
    Volume: 571, P: 205-210

  • Drugs that induce redifferentiation of cancer cells are efficient only in some subtypes of AML. The authors show that sensitivity to pro-differentiation drugs such as ATRA can be induced by co-treatment with epigenetic drugs. An inhibitor of histone demethylase, LSD1, safely used as an antidepressant in humans, reprograms AML cells and makes them sensitive to the effects of ATRA in vitro and in vivo, suggesting that epigenetic interventions can increase response to cancer treatments.

    • Tino Schenk
    • Weihsu Claire Chen
    • Arthur Zelent
    Research
    Nature Medicine
    Volume: 18, P: 605-611