Melanie Mark et al demonstrate that RGS2, a protein associated with stress disorders, drives male aggression through the serotonergic system. They show that exogenous expression of RGS2 in serotogenic neurons augments aggression in male mice and rescues the docile phenotype of Rgs2 knockouts but does not affect anxiety.
- Melanie D. Mark
- Patric Wollenweber
- Stefan Herlitze
