Nature Search

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Krista Freimann
Anneke Brümmer
Kaur Alasoo
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis

Early intermittent feeding of mice with a high-cholesterol Western-type diet accelerates atherosclerosis compared with late continuous exposure to the Western-type diet, despite similar cumulative circulating LDL-C levels.

Minoru Takaoka
Xiaohui Zhao
Ziad Mallat
ResearchOpen Access04 Sept 2024
Nature

Volume: 634, P: 457-465
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

An expanded GWAS of birth weight and subsequent analysis using structural equation modeling and Mendelian randomization decomposes maternal and fetal genetic contributions and causal links between birth weight, blood pressure and glycemic traits.

Nicole M. Warrington
Robin N. Beaumont
Rachel M. Freathy
Research01 May 2019
Nature Genetics

Volume: 51, P: 804-814
Genetic susceptibility to Alzheimer’s disease and cardiometabolic risk from childhood

Eero A. Haapala
Saara Heinonen
Suvi Rovio
ResearchOpen Access05 Mar 2026
Pediatric Research

P: 1-6
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.

Xueping Liu
Dorte Helenius
Bjarke Feenstra
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Determinants of echocardiographic epicardial adipose tissue in a general middle-aged population - The Cardiovascular Risk in Young Finns Study

Behnoush Gustafsson
Suvi P. Rovio
Olli T. Raitakari
ResearchOpen Access25 May 2024
Scientific Reports

Volume: 14, P: 1-14
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study

Laurie A. Matthews
Suvi P. Rovio
Katja Pahkala
Research05 Nov 2018
European Journal of Clinical Nutrition

Volume: 73, P: 937-949
Genome-wide associations for birth weight and correlations with adult disease

Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

Momoko Horikoshi
Robin N. Beaumont
Rachel M. Freathy
Research28 Sept 2016
Nature

Volume: 538, P: 248-252
Association of leisure time physical activity with gut microbiota composition in early adulthood

Hanna-Mari Boelius
Anna-Katariina Aatsinki
Katja Pahkala
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
Prevention of atherosclerosis from childhood

In this Review, Raitakari and colleagues discuss the importance of initiating the prevention of atherosclerosis in early life and summarize the major paediatric programmes for the prevention of atherosclerotic cardiovascular disease.

Olli Raitakari
Katja Pahkala
Costan G. Magnussen
Reviews05 Jan 2022
Nature Reviews Cardiology

Volume: 19, P: 543-554
Intergenerational continuity of loneliness and potential mechanisms: Young Finns Multigenerational Study

Marko Elovainio
Kaisla Komulainen
Laura Pulkki-Råback
ResearchOpen Access05 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Associations of active commuting to school in childhood and physical activity in adulthood

Kaisa Kaseva
Irinja Lounassalo
Kasper Salin
ResearchOpen Access11 May 2023
Scientific Reports

Volume: 13, P: 1-10
Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

Anna Viitasalo
Theresia M. Schnurr
Tuomas O. Kilpeläinen
ResearchOpen Access22 Jul 2019
International Journal of Obesity

Volume: 43, P: 2007-2016

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Polygenic prediction of body mass index and obesity through the life course and across ancestries

A saturated map of common genetic variants associated with human height

The power of genetic diversity in genome-wide association studies of lipids

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Genetic susceptibility to Alzheimer’s disease and cardiometabolic risk from childhood

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Determinants of echocardiographic epicardial adipose tissue in a general middle-aged population - The Cardiovascular Risk in Young Finns Study

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study

Genome-wide associations for birth weight and correlations with adult disease

Association of leisure time physical activity with gut microbiota composition in early adulthood

Prevention of atherosclerosis from childhood

Intergenerational continuity of loneliness and potential mechanisms: Young Finns Multigenerational Study

Associations of active commuting to school in childhood and physical activity in adulthood

Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

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