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Showing 1–5 of 5 results
Advanced filters: Author: Katrin Eichelbaum Clear advanced filters

  • RNA-binding proteins (RBPs) are implicated in many biological functions. Here the authors expand the human and yeast RNA interactome identifying new and conserved RBPs, several of which with no prior function assigned to RNA biology or structural motifs known to mediate RNA-binding, and suggesting new roles of RNA as modulators of protein function.

    • Benedikt M. Beckmann
    • Rastislav Horos
    • Matthias W. Hentze
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Avian influenza A virus (IAV) strains replicate poorly in mammalian hosts, but mechanisms underlying species restriction are incompletely understood. Here, Bogdanow et al. show that avian and mammalian adapted IAV strains have evolved different RNA structure features for regulation of M segment RNA splicing.

    • Boris Bogdanow
    • Xi Wang
    • Matthias Selbach
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • A mRNA-interactome capture approach in embryonic stem cells (ESCs) has led to the identification of 283 novel RNA-binding protein (RBP) candidates, of which 68 are preferentially expressed in ESCs. Validation of two known E3 ubiquitin ligases as RBPs reveals an intriguing potential link between RNA biology and protein-modification pathways.

    • S Chul Kwon
    • Hyerim Yi
    • V Narry Kim
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1122-1130