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Showing 1–3 of 3 results
Advanced filters: Author: Katrin Nitz Clear advanced filters

  • Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell-specific functions of the most relevant CD40L-expressing cell types in atherosclerosis. Deficiency of T cell-derived CD40L reduces and stabilizes plaques through impaired Th1 polarization while platelet-derived CD40L ameliorates atherothrombosis.

    • Michael Lacy
    • Christina Bürger
    • Esther Lutgens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Genetic polymorphisms affect expression of the atypical chemokine receptor ACKR1 (Duffy) on nucleated erythrocyte precursors. Rot and colleagues show that loss of its expression alters hematopoiesis, yielding a distinct neutrophil population that rapidly exits the bloodstream to give an apparent ‘neutropenia’ phenotype.

    • Johan Duchene
    • Igor Novitzky-Basso
    • Antal Rot
    Research
    Nature Immunology
    Volume: 18, P: 753-761