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Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo

Tools enabling mechanistic studies of protein function are important for furthering developmental and cell biology research. Here, Tarbashevich et al. develop molecules that are activated by light to allow spatial and temporal control over RNA translation in live embryos.

Katsiaryna Tarbashevich
Atanu Ghosh
Erez Raz
ResearchOpen Access16 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Retention of paternal DNA methylome in the developing zebrafish germline

Germ cells are the means of transferring genetic information to the next generation. Here the authors characterise the DNA methylomes of zebrafish primordial germ cells and find that, unlike mammals, the zebrafish germ cells do not undergo genome-wide DNA demethylation but rather retain paternal DNA methylation patterns

Ksenia Skvortsova
Katsiaryna Tarbashevich
Ozren Bogdanovic
ResearchOpen Access11 Jul 2019
Nature Communications

Volume: 10, P: 1-13
E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

The arrival of migratory cells at their targets relies on following precise routes within tissues. Here the authors demonstrate that the cell adhesion molecule E-cadherin can control the path of cell migration by confining the site where bleb-type protrusions form within the cell front.

Cecilia Grimaldi
Isabel Schumacher
Erez Raz
ResearchOpen Access26 Oct 2020
Nature Communications

Volume: 11, P: 1-15
Repulsive cues combined with physical barriers and cell–cell adhesion determine progenitor cell positioning during organogenesis

The precise positioning of organ progenitor cells is essential for organ development and function. Here the authors use live imaging and mathematical modelling to show that the confinement of a motile progenitor cell population results from coupled physical barriers and cell-cell interactions.

Azadeh Paksa
Jan Bandemer
Erez Raz
ResearchOpen Access18 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

The formation of new blood vessels requires both polarized cell migration and coordinated control of endothelial cell contacts. Here, Cao and colleagues describe at the sub-cellular level the cytoskeletal and cell junction dynamics regulating these processes upon VEGF-induced cell elongation.

Jiahui Cao
Manuel Ehling
Hans Schnittler
ResearchOpen Access20 Dec 2017
Nature Communications

Volume: 8, P: 1-20

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Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo

Retention of paternal DNA methylome in the developing zebrafish germline

E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

Repulsive cues combined with physical barriers and cell–cell adhesion determine progenitor cell positioning during organogenesis

Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

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