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Showing 1–6 of 6 results
Advanced filters: Author: Kaushik Ragunathan Clear advanced filters

  • The stoichiometry of Hrd1, an integral membrane E3 ubiquitin ligase is critical to maintaining proteostasis in the endoplasmic reticulum. Here, the authors establish a single-molecule counting approach coupled with a single-molecule in vitro ubiquitination system to determine the functional stoichiometry of Hrd1.

    • Basila Moochickal Assainar
    • Kaushik Ragunathan
    • Ryan D. Baldridge
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • HP1 proteins are rapidly evolving heterochromatin factors that are essential for silencing. Here, the authors identify an interface where subtle amino acid changes can lead to novel epigenetic inheritance phenotypes, acting as an effector toggle switch to regulate the persistence of epigenetic memory.

    • Amanda Ames
    • Melissa Seman
    • Kaushik Ragunathan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Ribosomes assemble through the hierarchical addition of proteins to a ribosomal RNA scaffold. Here the authors use three-color single-molecule FRET to show how the dynamics of the rRNA dictate the order in which multiple proteins assemble on the 5′ domain of the E. coli 16S rRNA.

    • Sanjaya C. Abeysirigunawardena
    • Hajin Kim
    • Sarah A. Woodson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Three-colour fluorescence resonance energy transfer and molecular dynamics simulations are used to study the events occurring early in assembly of the 30S ribosome; within a non-native intermediate S4 ribosomal protein–16S RNA structure, S4 is capable of altering the RNA helix dynamics to facilitate conformation changes that enable subsequent protein binding.

    • Hajin Kim
    • Sanjaya C. Abeysirigunawarden
    • Sarah A. Woodson
    Research
    Nature
    Volume: 506, P: 334-338