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Showing 1–5 of 5 results
Advanced filters: Author: Kavitha Chinnaiya Clear advanced filters

  • During vertebrate limb patterning the morphogen Sonic Hedgehog (Shh) is produced by cells of the polarizing region (ZPA). Here, the authors show, using chick embryo grafting experiments, that the duration of Shh expression by ZPA cells is defined by a cell cycle clock that is started and can also be reset by changes in retinoic acid signalling.

    • Kavitha Chinnaiya
    • Cheryll Tickle
    • Matthew Towers
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • The specification of positional values along the proximo-distal axis (shoulder to digits) of the vertebrate limb is an unresolved issue. By using heterochronic transplants of distal mesenchyme, the authors show that the zeugopod and autopod (elbow to digits) are progressively specified in an intrinsically timed manner.

    • Patricia Saiz-Lopez
    • Kavitha Chinnaiya
    • Matthew Towers
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • The limb bud is patterned by crosstalk between the mesoderm and the overlying apical ectodermal ridge, but it has been difficult to determine the requirement for different ligands in this process. Here the authors use a chick wing explant system to show that fibroblast growth factors trigger a mesodermal programme that is key for timing limb bud patterning.

    • Sofia Sedas Perez
    • Caitlin McQueen
    • Matthew Towers
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The tuberal hypothalamus regulates a range of crucial physiological processes, including energy homeostasis and metabolism. This Review discusses the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes.

    • Marysia Placzek
    • Kavitha Chinnaiya
    • Seth Blackshaw
    Reviews
    Nature Reviews Endocrinology
    Volume: 21, P: 118-130