Heissmeyer and colleagues show that TCR stimulation-induced cell death is controlled by N6-methyladenosine (m6A) modification of Orai1 and Ripk1 mRNAs. m6A is deposited by a ‘writer’ complex of Wtap and the N6-methyltransferase and bound by the ‘reader’ protein Ythdf2. T cells lacking Wtap exhibit enhanced Ca2+ entry in response to TCR ligation and decreased survival due to activation-induced cell death.
- Taku Ito-Kureha
- Cristina Leoni
- Vigo Heissmeyer
