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Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4⁺ T cells

CD4⁺ T cells are readily detected with class II MHC dimers.

Kenji Sugata
Yukiko Matsunaga
Naoto Hirano
Research01 Mar 2021
Nature Biotechnology

Volume: 39, P: 958-967
HLA-DP^84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway

MHC class I and II molecules generally present endogenous and exogenous peptides, respectively, through distinct mechanisms. Here, the authors show that the class II molecule HLA-DP^84Glyuses both class I and II mechanisms to constitutively present peptides.

Yuki Yamashita
Mark Anczurowski
Naoto Hirano
ResearchOpen Access10 May 2017
Nature Communications

Volume: 8, P: 1-14
DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

Adoptive T cell therapy using an allogeneic T cell graft is an encouraging therapeutic approach in cancer, but issues such as graft-versus-host disease can hinder applicability. Here, the authors show that DOT1L inhibition or DUSP6 overexpression in T cells attenuates graft-versus-host disease but retains anti-tumour activity in mouse models.

Yuki Kagoya
Munehide Nakatsugawa
Naoto Hirano
ResearchOpen Access15 May 2018
Nature Communications

Volume: 9, P: 1-17
A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

Optimal T cell activation requires signaling through the T cell receptor (signal 1), a co-stimulatory receptor (signal 2) and a cytokine receptor (signal 3), yet most chimeric antigen receptors (CARs) lack a domain to transduce signal 3. Kagoya et al. now report their development of a new CAR that incorporates a JAK–STAT cytokine signaling domain and mediates potent antitumor effects.

Yuki Kagoya
Shinya Tanaka
Naoto Hirano
Research05 Feb 2018
Nature Medicine

Volume: 24, P: 352-359
Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP^84Gly

Mark Anczurowski
Yuki Yamashita
Naoto Hirano
ResearchOpen Access19 Mar 2018
Scientific Reports

Volume: 8, P: 1-13
CD4⁺ and CD8⁺ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells

Munehide Nakatsugawa
Muhammed A. Rahman
Naoto Hirano
ResearchOpen Access31 Mar 2016
Scientific Reports

Volume: 6, P: 1-15

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Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells

HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP84Gly

CD4+ and CD8+ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells

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Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4⁺ T cells

HLA-DP^84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway

Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP^84Gly

CD4⁺ and CD8⁺ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells