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Showing 1–7 of 7 results
Advanced filters: Author: Kayvon Pedram Clear advanced filters
  • Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix in living samples.

    • Antonio Fiore
    • Guoqiang Yu
    • Kayvon Pedram
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 1070-1080
  • Lysosome-targeting chimaeras—in which a small molecule or antibody is connected to a glycopeptide ligand to form a conjugate that can bind a cell-surface lysosome-shuttling receptor and a protein target—are used to achieve the targeted degradation of extracellular and membrane proteins.

    • Steven M. Banik
    • Kayvon Pedram
    • Carolyn R. Bertozzi
    Research
    Nature
    Volume: 584, P: 291-297
  • MUC1 is a heavily glycosylated protein on the cell surface. Here the authors show that MUC1 prefers negative over positive membrane curvature due to its bulky size, enabling MUC1 to avoid endocytosis and surface removal based on curvature preference.

    • Chih-Hao Lu
    • Kayvon Pedram
    • Bianxiao Cui
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16
  • Mucin-domain glycoproteins are densely O-glycosylated proteins with unique secondary structure that imparts a large influence on cellular environments. Here, the authors develop a technique to selectively enrich and characterize mucin-domain glycoproteins from cell lysate and patient biofluids.

    • Stacy A. Malaker
    • Nicholas M. Riley
    • Carolyn R. Bertozzi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • Enrichment of biotinylated peptides using an anti-biotin antibody results in substantially improved biotinylation site identifications by mass spectrometry compared to traditional streptavidin-based biotinylated protein enrichment.

    • Namrata D Udeshi
    • Kayvon Pedram
    • Steven A Carr
    Research
    Nature Methods
    Volume: 14, P: 1167-1170