The authors report that Hes5, a Notch effector gene, is serially activated by mammalian glial cells missing (Gcm) and later by the canonical Notch pathway. Loss of both Gcm1 and Gcm2 and subsequent lack of Hes5 upregulation in the neuroepithelium leads to impaired induction of neural stem cells.
- Seiji Hitoshi
- Yugo Ishino
- Kazuhiro Ikenaka
