Epithelia continually undergo apoptosis, but the physiological importance of this is unclear. Shibuya and colleagues show that apoptotic epithelial cells bind the glycoprotein CD300a on a dendritic cell subset at barrier surfaces and this negatively regulates commensal-driven Treg cell proliferation.
- Chigusa Nakahashi-Oda
- Kankanam Gamage Sanath Udayanga
- Akira Shibuya