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A co-stimulatory signal via the coinhibitory TIGIT

TIGIT, a coinhibitory receptor that suppresses excessive immune responses, also promotes tissue regeneration by functioning as a co-stimulatory receptor in regulatory T cells via the TIGIT–TCR–BLIMP1–AREG axis during viral infection.

Kazuko Shibuya
Akira Shibuya
News & Views24 Oct 2025
Nature Immunology

Volume: 26, P: 1845-1846
Fcα/μ receptor mediates endocytosis of IgM-coated microbes

Akira Shibuya
Norihisa Sakamoto
Hiromitsu Nakauchi
Research01 Nov 2000
Nature Immunology

Volume: 1, P: 441-446
Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Tsuyoshi Iizuka
Takazo Shibuya
Hisayoshi Yurimoto
Research10 Sept 2025
Nature

Volume: 646, P: 62-67
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions

Immunoglobulin E–mediated crosslinking of FɛRI receptors can lead to life-threatening anaphylaxis in sensitized people. Shibuya and colleagues identify a phosphatase-recruiting inhibitory receptor, Allergin-1, that suppresses mast cell degranulation induced by immunoglobulin E–FɛRI.

Kaori Hitomi
Satoko Tahara-Hanaoka
Akira Shibuya
Research06 Jun 2010
Nature Immunology

Volume: 11, P: 601-607
Apoptotic epithelial cells control the abundance of T_reg cells at barrier surfaces

Epithelia continually undergo apoptosis, but the physiological importance of this is unclear. Shibuya and colleagues show that apoptotic epithelial cells bind the glycoprotein CD300a on a dendritic cell subset at barrier surfaces and this negatively regulates commensal-driven T_reg cell proliferation.

Chigusa Nakahashi-Oda
Kankanam Gamage Sanath Udayanga
Akira Shibuya
Research08 Feb 2016
Nature Immunology

Volume: 17, P: 441-450
Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration

Inflammatory monocytes play an important role in host defense against infections. Here the authors provide insights into the mechanism behind the recruitment of inflammatory monocytes to sites of infection by demonstrating the involvement of Toll-like receptor 4 and MAIR-II immunoreceptors in this process.

Naoya Totsuka
Yun-Gi Kim
Akira Shibuya
ResearchOpen Access19 Aug 2014
Nature Communications

Volume: 5, P: 1-10
Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis.

Shin-ichiro Honda
Kazuki Sato
Akira Shibuya
ResearchOpen Access05 May 2016
Nature Communications

Volume: 7, P: 1-10
Gene deletions in Japanese patients with Duchenne and Becker muscular dystrophy

Jun-ichi Asano
Shunji Tomatsu
Tadao Orii
Research01 Jun 1990
Japanese journal of human genetics

Volume: 35, P: 159-168
Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4⁺ T cell costimulation

Eri Takenaka
Anh Van Vo
Kazuko Shibuya
ResearchOpen Access12 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS

A genome-wide association study in Japanese patients with ALS identifies rs113161727 at the ADAM29-GPM6A locus as a modifier of age at onset and links it to GPM6A upregulation.

Ryoichi Nakamura
Genki Tohnai
Gen Sobue
ResearchOpen Access05 Dec 2025
Communications Biology

Volume: 8, P: 1-11
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

Atsuo Sasaki
Takaharu Taketomi
Akihiko Yoshimura
Research22 Apr 2003
Nature Cell Biology

Volume: 5, P: 427-432
Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation

Yoshiyuki Nakamura
Takashi Matsuzaka
Akira Shibuya
ResearchOpen Access05 Dec 2018
Cell Death & Disease

Volume: 9, P: 1-11
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation

Tatsuro Hirayama
Taiga Miyazaki
Hiroshi Mukae
ResearchOpen Access02 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis

Gen Sobue, Masao Nagasaki and colleagues report a genome-wide association study for amyotrophic lateral sclerosis (ALS) in a large, multi-ethnic cohort comprising Japanese, Chinese, and European ancestry populations. They find a significant association to variants within the ACSL5 gene and identify novel associations with 4 additional genes using a gene-based approach.

Ryoichi Nakamura
Kazuharu Misawa
Gen Sobue
ResearchOpen Access23 Sept 2020
Communications Biology

Volume: 3, P: 1-9
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14

Search

A co-stimulatory signal via the coinhibitory TIGIT

Fcα/μ receptor mediates endocytosis of IgM-coated microbes

Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions

Apoptotic epithelial cells control the abundance of T_reg cells at barrier surfaces

Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration

Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

Gene deletions in Japanese patients with Duchenne and Becker muscular dystrophy

Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4⁺ T cell costimulation

A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

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