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Distinct roles of monkey OFC-subcortical pathways in adaptive behavior

The OFC is at the core of value-based adaptive decision-making. Here, the authors demonstrate dissociable contributions of primate OFC-subcortical pathways to different behavioral strategies by combining chemogenetics with a model-fitting approach.

Kei Oyama
Kei Majima
Takafumi Minamimoto
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Fast, accurate, and interpretable decoding of electrocorticographic signals using dynamic mode decomposition

Dynamic mode decomposition captures spatiotemporal patterns in neural activity such as human electrocorticographic signals. This study presents a novel method for vectorising the dynamic modes to increase the speed and accuracy of neural decoding.

Ryohei Fukuma
Kei Majima
Takufumi Yanagisawa
ResearchOpen Access18 May 2024
Communications Biology

Volume: 7, P: 1-11
Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex

Episodic or declarative memory is thought to be encoded in the ensemble firing of spatially distributed neurons. Here the authors use high-density electrical recordings to show that some areas in the primate temporal cortex develop patterns of theta activity that are similar for pairs of remembered objects.

Kiyoshi Nakahara
Ken Adachi
Isao Hasegawa
ResearchOpen Access10 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

Kei Asayama
Takayoshi Ohkubo
Yutaka Imai
Research16 Aug 2012
Hypertension Research

Volume: 35, P: 1102-1110

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Distinct roles of monkey OFC-subcortical pathways in adaptive behavior

Fast, accurate, and interpretable decoding of electrocorticographic signals using dynamic mode decomposition

Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

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