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Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation

Plants respond to gibberellins via GID1-dependent degradation of DELLA proteins. Here, Nemoto et al. show that the gibberellin response is positively regulated by tyrosine phosphorylation of GARU, an E3 ubiquitin ligase that mediates degradation of GID1.

Keiichirou Nemoto
Abdelaziz Ramadan
Tatsuya Sawasaki
ResearchOpen Access17 Oct 2017
Nature Communications

Volume: 8, P: 1-15
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Identification of a new gibberellin receptor agonist, diphegaractin, by a cell-free chemical screening system

A drug screening system identifies a gibberellin receptor agonist, diphegaractin, found to exert gibberellin-like activity in the growth and maturation of grapes, lettuce, Arabidopsis, and citrus fruit.

Akira Nozawa
Ryoko Miyazaki
Tatsuya Sawasaki
ResearchOpen Access09 May 2023
Communications Biology

Volume: 6, P: 1-11
Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate herbivore resistance

Uemura et al. study the mechanism of herbivore resistance in soybean and Arabidopsis. They show that receptor-like kinases (HAK1/2) respond to a polysaccharide in the oral secretions of Spodoptera litura and then interact with PBL27, resulting in an ethylene-dependent herbivore resistance.

Takuya Uemura
Masakazu Hachisu
Gen-ichiro Arimura
ResearchOpen Access08 May 2020
Communications Biology

Volume: 3, P: 1-11
OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability

Satoshi Ogawa
Koji Miyamoto
Kazunori Okada
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Identification of new abscisic acid receptor agonists using a wheat cell-free based drug screening system

Keiichirou Nemoto
Makiko Kagawa
Tatsuya Sawasaki
ResearchOpen Access09 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17

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Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Identification of a new gibberellin receptor agonist, diphegaractin, by a cell-free chemical screening system

Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate herbivore resistance

OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability

Identification of new abscisic acid receptor agonists using a wheat cell-free based drug screening system

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

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