Degeneration of Purkinje neurons is the cause of ataxia in several neurodegenerative syndromes. Muguruma and colleagues describe a protocol for deriving Purkinje progenitors and neurons from mouse ES cells. Transplanted progenitors were able to integrate into the embryonic cerebellum with an efficiency of about 3% and adopt a Purkinje neuron phenotype.
- Keiko Muguruma
- Ayaka Nishiyama
- Yoshiki Sasai
